Influencing factors of small intestinal ischemia in elderly patients with incarcerated hernia / 中华外科杂志

Objective: To investigate the factors influencing small intestinal ischemia in elderly patients with incarcerated hernia. Methods: The clinical data of 105 elderly patients admitted for surgical procedures of incarcerated hernia at Department of General Surgery, Huadong Hospital between January 2014 and December 2021 were retrospectively analyzed. There were 60 males and 45 females, aged (86.1±4.3) years (range: 80 to 96 years). They were divided into normal group (n=55) and ischemic group (n=50) according to intraoperative intestinal canal condition. The t test, χ2 test and Fisher's exact probability method were used for the univariate analysis of the factors that influence intestinal ischemia in patients, and Logistic regression was used for multifactorial analysis. Results: In all patients, 18 patients (17.1%) had irreversible intestinal ischemia with bowel resection. Six patients died within 30 days, 3 cases from severe abdominal infection, 2 cases from postoperative exacerbation of underlying cardiac disease, and 1 case from respiratory failure due to severe pulmonary infection. The results of the univariate analysis showed that there were differences in gender, history of intussusception, duration of previous hernia, white blood cell count, neutrophil percentage, C-reactive protein, type of incarcerated hernia, and preoperative intestinal obstruction between the two groups (all P<0.05). The Logistic regression results showed that the short time to the previous hernia (OR=0.892, 95%CI 0.872 to 0.962, P=0.003), high C-reactive protein (OR=1.022, 95%CI 1.007 to 1.037, P=0.003), non-indirect incarcerated hernia (OR=10.571, 95%CI 3.711 to 30.114, P<0.01) and preoperative intestinal obstruction (OR=6.438, 95%CI 1.762 to 23.522, P=0.005) were independent risk factors for the development of intestinal ischemia in elderly patients with incarcerated hernia. Conclusions: The short duration of the previous hernia, the high values of C-reactive proteins, the non-indirect incarcerated hernia, and the preoperative bowel obstruction are influencing factors for bowel ischemia in elderly patients with incarcerated hernia. A timely operation is necessary to reduce the incidence of intestinal necrosis and improve the prognosis.

Two-year clinical outcomes following lower limb endovascular revascularisation for chronic limb-threatening ischaemia at a tertiary Asian vascular centre in Singapore

INTRODUCTION@#Percutaneous transluminal angioplasty (PTA) is commonly used to treat patients with chronic limb-threatening ischaemia (CLTI). This study aimed to examine the mortality and functional outcomes of patients with CLTI who predominantly had diabetes mellitus in a multi-ethnic Asian population in Singapore.@*METHODS@#Patients with CLTI who underwent PTA between January 2015 and March 2017 at the Vascular Unit at Singapore General Hospital, Singapore, were studied. Primary outcome measures were 30-day unplanned readmission, two-year major lower extremity amputation (LEA), mortality rates, and ambulation status at one, six and 12 months.@*RESULTS@#A total of 221 procedures were performed on 207 patients, of whom 184 (88.9%) were diabetics. The one-, six- and 12-month mortality rate was 7.7%, 16.4% and 21.7%, respectively. The two-year LEA rate was 30.0%. At six and 12 months, only 96 (46.4%) and 93 (44.9%) patients were ambulant, respectively. Multivariate analysis revealed that preoperative ambulatory status, haemoglobin, Wound Ischaemia and foot Infection (WIfI) score, and end-stage renal failure (ESRF) were independent predictors of one-year ambulatory status. Predictors of mortality at one, six and 12 months were ESRF, preoperative albumin level, impaired functional status and employment status.@*CONCLUSION@#PTA for CLTI was associated with low one-year mortality and two-year LEA rates but did not significantly improve ambulation status. ESRF and hypoalbuminaemia were independent predictors of mortality. ESRF/CKD and WIfI score were independent predictors of loss of ambulation at six months and one year. We need better risk stratification for patients with CLTI to decide between initial revascularisation and an immediate LEA policy.

Resultados en el corto y mediano plazo del tratamiento endovascular en la enfermedad arterial obstructiva infrapoplítea en pacientes con isquemia crítica de una extremidad / Short to midterm results after endovascular approach in critical limb isquemia in patients with below-the-knee arterial disease

Resumen Objetivo: Mostrar los resultados en el corto y mediano plazo del tratamiento endovascular de angioplastia transluminal percutánea (ATP) con balón en pacientes en estado de isquemia crítica por enfermedad arterial obstructiva infrapoplítea. Materiales y Método: Estudio descriptivo, observacional, retrospectivo. Se incluyeron los pacientes hospitalizados entre 2009 y 2018 por isquemia crítica Fontaine III o IV sometidos a una ATP del territorio infrapoplíteo. Se observó como objetivos primarios la preservación de la extremidad afectada y la mortalidad posoperatoria a un año plazo, y como objetivos secundarios los procedimientos adicionales en pacientes con lesiones o necrosis distales, estadía hospitalaria, complicaciones posoperatorias y necesidad de reintervención. Resultados: Se incluyeron 42 pacientes con un promedio de edad de 66 años (46-82), con importantes comorbilidades. Un 83,3% ingresó en etapa Fontaine IV. En 16 casos se realizó una angioplastia percutánea en más de una arteria. No se colocó stents. Se presentaron complicaciones en 3 pacientes, 2 requirieron una amputación mayor y en otro se debió efectuar un nuevo procedimiento endovascular de rescate. La estadía hospitalaria promedio fue 22 días. No hubo mortalidad precoz posprocedimiento. La mortalidad global a un año fue 9,5%. A todos los pacientes en etapa Fontaine IV se les efectuó algún procedimiento adicional, a 31 una amputación menor, 3 cerraron sus lesiones por segunda intención y en otro se realizó un injerto dermo-epidérmico. De los 35 pacientes con seguimiento, 77% preservó su extremidad a un año. Conclusión: La reparación endovascular mediante una angioplastia percutánea en estos casos es un procedimiento seguro y tiene una alta tasa de preservación de la extremidad inicial a un año de seguimiento.

Aim: Show initial and midterms results of endovascular Percutaneous Transluminal Angioplasty (PTA) in critical limb isquemia (CLI) patients caused by below-the-knee arterial disease. Materials and Method: Observational, descriptive and retrospective study. 42 CLI patients admitted in our hospital from 2009 until 2018 with Fontaine III or IV treated by PTA in infrapopliteal arteries were analyzed, collecting demographic, clinical and surgical characteristics, additional procedures in Fontaine IV, hospital stay, postoperative complications, need of reintervention, limb preservation and mortality with one year follow-up after procedure. Results: 42 patients, average age 66 year-old (46-82), with significant comorbidities. Fontaine IV stage patients were 83.3%. In 16 cases more than one artery was intervened. No stent revascularization was performed. Complications occurred in 3 patients, 2 required major amputation and an urgent endovascular reintervention was required in another. Average hospital stay was 22 days with no post-operative mortality. One-year global mortality was 9.5 One-year follow-up in 35 patients shows that 77% preserved their limb. Conclusión: Percutaneous transluminal angioplasty procedure in this patients has a high rate of limb preservation in a one-year follow-up. There was no post-operative mortality.

Acute arterial ischemia in COVID-19 / Isquemia arterial aguda em pacientes com COVID-19

Abstract Since the coronavirus pandemic set in in Spain in March 2020, a noteworthy increase in the incidence of acute limb ischemia (ALI) has been observed. It has been recently discovered that SARS-CoV 2 may lead to ALI secondary to arterial thrombosis. Elevation of D-dimer (DD) in patients with coronavirus infection (COVID-19) indicates that a hypercoagulable state causes acute arterial thrombosis. A remarkably high DD elevation has been reported to be a poor prognosis factor in COVID-19. The ways in which SARS-CoV 2 results in arterial thrombosis may be multiple. On the other hand, surgical revascularization for ALI is associated with poor outcomes in COVID-19 patients, probably in relation to hypercoagulability. Here, we describe two ALI cases in patients who required urgent surgical treatment for limb salvage and were positive for the novel coronavirus infection (COVID 19).

Resumo Desde que a pandemia pelo novo coronavírus se estabeleceu na Espanha, em março de 2020, um aumento notável da incidência de isquemia aguda de membros foi observado. Recentemente, descobriu-se que o coronavírus 2 causador da síndrome respiratória aguda grave (SARS-CoV-2) pode ocasionar isquemia aguda de membros secundária à trombose arterial. A elevação do D-dímero em pacientes acometidos pela doença do novo coronavírus (COVID-19) indica o estado de hipercoagulabilidade como causa da trombose arterial aguda. Vale destacar que a alta elevação do D-dímero foi relatada como um fator de prognóstico reservado na COVID-19. Há diversas maneiras pelas quais o SARS-CoV-2 pode resultar em trombose arterial. Em pacientes com COVID-19, a revascularização cirúrgica para isquemia aguda de membros está associada a desfechos desfavoráveis, provavelmente relacionados a hipercoagulabilidade. Descrevemos dois casos de isquemia aguda de membros de pacientes que necessitaram de tratamento cirúrgico de urgência para salvamento de membro e que haviam testado positivo para COVID-19.

Síndrome de hiperviscosidade em paciente com mieloma múltiplo / Hyperviscosity syndrome in multiple myeloma patients

O mieloma múltiplo é uma neoplasia progressiva e incurável de células B, caracterizado pela proliferação desregulada e clonal de plasmócitos na medula óssea. A síndrome de hiperviscosidade é uma das complicações relacionadas às gamopatias monoclonais, sendo considerada emergência oncológica. O objetivo deste estudo foi descrever o quadro clínico de um paciente diagnosticado com mieloma múltiplo que apresentou síndrome de hiperviscosidade, avaliando a prevalência de sinais e sintomas, bem como características fisiopatológicas dessa entidade clínica. Foi revisado o prontuário de um paciente internado na enfermaria da Clínica Médica do Hospital Regional do Cariri (CE) no período de junho a julho de 2018. Além disso, foi realizada revisão de literatura em base de dados (PubMed®) direcionada ao tema proposto. O diagnóstico de mieloma múltiplo foi comprovado por mielograma, sendo prontamente iniciada a corticoterapia e avaliada a resposta clínica após essa terapêutica. Apesar de incomum e menos frequentemente relacionada ao mieloma múltiplo, a síndrome de hiperviscosidade está relacionada a uma grande taxa de mortalidade quando apresenta diagnóstico tardio. A terapia de primeira linha indicada para a síndrome de hiperviscosidade foi a plasmaferese, no entanto, as condições clínicas (instabilidade hemodinâmica) impossibilitaram sua realização. O desfecho deste caso foi o óbito do paciente. Concluiu-se que o diagnóstico precoce e a intervenção terapêutica estão diretamente relacionados à ocorrência de menor incidência de complicações relacionadas ao mieloma múltiplo e à síndrome de hiperviscosidade.

Multiple myeloma is a progressive and incurable B-cell neoplasm characterized by unregulated and clonal proliferation of plasmocytes in the bone marrow. Hyperviscosity syndrome is one of the complications related to monoclonal gammopathies and is considered an oncological emergency. The aim of this study was to describe the clinical condition of a patient diagnosed with multiple myeloma who presented hyperviscosity syndrome, evaluating the prevalence of symptoms and signs, as well as the pathophysiological characteristics of this clinical entity. The medical records of a patient admitted to the Internal Medicine ward of the Hospital Regional do Cariri (CE) from June to July of 2018 were reviewed. In addition, we conducted a literature review in a database (PubMed®) directed to the theme proposed. The diagnosis of multiple myeloma was confirmed by myelogram, and corticosteroid therapy was promptly initiated and the clinical response was evaluated after this therapy. Although uncommon and less frequently related to multiple myeoloma, hyperviscosity syndrome is related to a high mortality rate when diagnosed late. The first line therapy indicated to hyperviscosity syndrome was plasmapheresis; however, the clinical conditions (hemodynamic instability) precluded its performance. The outcome of this case was the patient's death. Thus, it was concluded that early diagnosis and therapeutic intervention are directly related to the occurrence of lower incidence of complications related to multiple myeloma and hyperviscosity syndrome.

Manejo endovascular de la isquemia crítica distal: análisis de una serie contemporánea

Background: Chronic limb ischemia can lead to high rates of limb loss and mortality. Open surgery is the gold standard for treatment of distal disease. Endovascular surgery should have less complications with similar outcomes. Aim: To report a cohort of patients with distal arterial disease treated with endovascular surgery at our institution. Material and Methods: Review of angioplasty records of patients undergoing distal lower extremity endovascular procedures between 2016 and 2019. Demographics, comorbidities, form of presentation, type of intervention, perioperative complications, and length of stay were analyzed. The primary outcomes were wound healing, reinterventions and freedom from major amputation. Secondary outcomes were overall survival and amputation-free survival. Results: Forty-eight limbs of 41 patients with a mean age 75 years (78% males) were treated. Ninety-three percent had hypertension, 88% diabetes, 30% chronic kidney disease. 73% presented with major wounds. Plain balloon and drug coated balloon angioplasties were carried out in 65 and 31% of procedures respectively, with no difference in results. In 46% of the cases, only chronic total occlusions were treated. Wound healing was achieved in 85% of procedures and 90% of patients were free from amputation at one year of follow up. Complications were observed in 18% of procedures, perioperative mortality was 2% and one-year survival was 76%. Conclusions: Endovascular therapy achieves high rates of wound healing and freedom from amputation with low perioperative mortality and moderate complication rates.

Management of lower limb ischemia during operative repair of acute type a aortic dissection by distal crossover grafts: a case series

Abstract Objective: To describe our experience of nine patients with extra-anatomical bypass for clinically ischemic distal limb during repair of acute Type A aortic dissection (ATAAD). Methods: We retrospectively examined a series of nine patients who underwent surgery for ATAAD. We identified a subset of the patients who presented with concomitant radiographic and clinical signs of lower limb ischemia. All but one patient (axillobifemoral bypass) underwent femorofemoral crossover grafting by the cardiac surgeon during cooling. Results: One hundred eighty-one cases of ATAAD underwent surgery during the study period with a mortality of 19.3%. Nine patients had persistent clinical evidence of lower limb ischemia (4.9%) and underwent extra-anatomical bypass during cooling. Two patients underwent additional fasciotomies. Mean delay from symptoms to surgery in these nine patients was 9.5 hours. Two patients had bilateral amputations despite revascularisation and, of note, had long delays in presentation for surgery (> 12 hours). There were no mortalities during these inpatient episodes. Outpatient radiographic follow-up at the first opportunity demonstrated 100% patency. Conclusion: Our experience suggests that, during complicated aortic dissection, limb ischemia may have a devastating outcome including amputation when diagnosis and referral are delayed. Early diagnosis and surgery are crucial in preventing this potentially devastating complication.

Impacto do tempo de isquemia na análise de expressão gênica global em tecidos criopreservados / Impact of cold ischemia on global gene expression in cryopreserved tissues

O perfil de expressão gênica tem passado do cenário da pesquisa básica para a prática clínica, sendo cada vez mais utilizado como ferramenta na classificação de subtipos moleculares do câncer. No entanto, deve-se ter cautela ao interpretar as assinaturas gênicas, uma vez que os métodos de manuseio e preservação da amostra podem afetar a expressão gênica. "Isquemia fria", quando aplicada à coleta e preservação de tecidos para pesquisa, refere-se ao período transcorrido desde a retirada do órgão do corpo e coleta da amostra, até o momento do seu congelamento em nitrogênio líquido. O objetivo geral deste trabalho foi avaliar o impacto do tempo de isquemia fria na expressão gênica global pela técnica de microarray em um modelo animal. Avaliamos 3 órgãos (pulmão, fígado e rim) de 52 camundongos (Mus musculus C57Bl/6), gerando 312 tecidos submetidos a diferentes tempos de isquemia (zero ou referência, 15, 30, 45 e 60 minutos). A expressão gênica global foi avaliada na plataforma SurePrint G3 Mouse GE 8x60K Microarray, que cobre o genoma completo do camundongo. Como resultado deste trabalho, os RNA totais extraídos tiveram alta qualidade (RIN médio de 9,4) e observamos alterações em genes que podem ser atribuídas ao processo isquêmico per se (p<0.05 e fold-change |2|). Alguns desses genes são conhecidamente relacionados ao câncer: fatores de transcrição (Fos, Hif3A), oncogenes (Ret, Srsf3), supressores tumorais (Btg1, Hnf1a), genes envolvidos no reparo do DNA, diferenciação e atividades de quinase. Esses genes devem ser olhados com cautela nas assinaturas genômicas para um desempenho analítico mais confiável. Foram encontradas variações de expressão gênica relacionadas a processos de controle de íons intracelulares e controle do pH. Evidenciou-se a importância da criopreservação imediata do tecido, ou, pelo menos, o mais rápido possível após a coleta, visando minimizar os efeitos de variação da expressão gênica decorrentes da isquemia (AU)

Gene expression profile has been moved from basic research to clinical practice, and it is increasingly being used as a tool in the classification of molecular subtypes in cancer. However, caution should be exercised when interpreting gene signatures, as sample handling and preservation methods may affect gene expression. "Cold ischemia", when applied to tissue collection and preservation for research, refers to the period from organ removal from the body and sample collection until it is frozen in liquid nitrogen. The general objective of this work was to evaluate the impact of cold ischemia time on global gene expression by microarray technique in an animal model. We evaluated 3 organs (lung, liver and kidney) from 52 mice (Mus musculus C57Bl / 6), generating 312 tissues submitted to different ischemia times (zero or reference, 15, 30, 45 and 60 minutes). Global gene expression was evaluated on the SurePrint G3 Mouse GE 8x60K Microarray platform that covers the complete mouse genome. As a result of this work, the extracted total RNAs had high quality (mean RIN of 9.4) and we evidenced changes in genes that can be attributed to the ischemic process per se (p <0.05 and fold-change | 2 |). Some of these genes are known to be related to cancer: transcription factors (Fos, Hif3A), oncogenes (Ret, Srsf3), tumor suppressors (Btg1, Hnf1a), genes involved in DNA repair, differentiation and kinase activities. These genes should be viewed with caution in genomic signatures for more reliable analytical performance. Gene expression variations related to intracellular ion control and pH control processes were observed. The importance of immediate tissue cryopreservation, or at least as soon as possible after collection, was evidenced in order to minimize the effects of gene expression variation resulting from ischemia (AU)

Fluorescent test accurately predicts leak of ischemic colon anastomosis in rats

Abstract Purpose: To investigate if fluorescein fluorescent test can predict dehiscence in a model of ischemic colonic anastomosis in rats. Methods: This experimental controlled trial randomly assigned 55 rats to four groups. Anastomoses were performed in non-ischemic colon segments (control group) and in ischemic colon segments measuring 1, 2 or 3 cm long (groups 1, 2 and 3, respectively). Fluorescein was injected and the tissues were examined under ultraviolet light. Seven days later, a second-look surgery was performed to check for the presence or absence of anastomosis dehiscence. Results: Twenty-four rats presented anastomotic dehiscence during the second-look surgery. Reticular and nonfluorescent patterns were significantly associated with the occurrence of anastomotic dehiscence. Fluorescein fluorescence had a sensitivity of 95.8%, specificity of 89.2%, positive predictive value of 88.4%, negative predictive value of 96.2%, and accuracy of 92.3% to predict anastomotic dehiscence. Conclusion: Fluorescein fluorescent test can accurately predict leak in a model of ischemic colonic anastomosis in rats.

Evaluation of the effect of allopurinol as a protective factor in post ischemia and reperfusion inflammation in Wistar rats

PURPOSE: To investigate the potential protective effect of allopurinol on reperfusion injury by determining the inflammatory response through the measurement of tumor necrosis factor-alpha (TNF-alpha). METHODS: Sixty rats were distributed into two groups: control and allopurinol and each group was divided into three subgroups, ischemia for two hours, ischemia for three hours and ischemia simulation. Allopurinol group rats received 100mg/kg dose of allopurinol, whereas control group rats received an equivalent dose of saline. Clamping of the infrarenal aorta was performed for two or three hours depending on the subgroup. Ischemia simulation subgroups did not suffer ischemia, just aortic dissection, and maintenance for three hours. After 72 hours of reperfusion, blood was collected by cardiac puncture for TNF-alpha measurement. RESULTS: Allopurinol reduced TNF-alpha significantly (p <0.001) when compared to the matching control subgroups (control X allopurinol in ischemia for two hours and for three hours). CONCLUSION: Allopurinol reduced the concentrations of serum TNF-alpha when used at different times of ischemia followed by reperfusion, which might indicate reduction of the inflammation provoked by the reperfusion injury.

Cierre primario de fasciotomías con técnica con elásticos: experiencia nacional multicéntrica / Fasciotomy closure technique with vessel loops

Aim: Present and describe the progressive fasciotomy closure technique with vessel loops. Methods: Progressive and multicentric study in the period between June of 2007 and June of 2011. Results: In 2007 we initiated the complementary treatment for fasciotomy closure related to compartment syndrome or acute ischemia cases. Progressive closure with vessel loops, the shoelace technique. In 2010's preliminary report, we published a total of 56 fasciotomies closed by this technique, with an average closure time of 9.5 +/- 3.31 days. Current report is the result of a 4 years prospective study intending to prove that is possible to associate this technique to the initial management of fasciotomies closure. This final report shows a total of 122 fasciotomies cases closed in 7.9 +/- 3.31 days, without skin grafts. Conclusion: The technique is easy to learn, reproducible and not expensive. Results show that this technique is useful in reduce the time for fasciotomy closure.

Objetivos: Presentar y describir la técnica de cierre progresivo de fasciotomías con elásticos. Métodos: Estudio prospectivo multicéntrico realizado en Santiago de Chile entre junio de 2007 y junio de 2011. Resultados: En el año 2007 se inició un protocolo de manejo del cierre de las fasciotomías realizadas a pacientes portadores de síndrome compartimental o isquemia aguda de extremidades. Utilizando una técnica de entrelazado con elásticos vasculares se realizó el cierre de las fasciotomías. En el 2010 se publicó un reporte preliminar, presentando una serie de 56 fasciotomías cerradas con esta técnica, con un promedio de cierre de 9,5 +/- 3,31 días. La serie actual es el resultado de un estudio prospectivo de 4 años de duración que ha buscado demostrar que resulta posible asociar esta técnica con elásticos al manejo inicial del cierre de las fasciotomías. Nuestro reporte final muestra un total de 122 fasciotomías cerradas en un promedio de 7,9 +/- 3,31 días sin requerir de injertos de piel. Conclusiones: Presentamos una técnica quirúrgica fácil de reproducir, de bajo costo y con buenos resultados. El uso de elásticos vasculares muestra beneficios en el tiempo de cierre de las fasciotomías.

RE: Percutaneous Angioplasty in Diabetic Patients with Critical Limb Ischemia

No abstract available.

Diabetes-related lower-extremity amputation incidence and risk factors: a prospective seven-year study in Costa Rica / Incidencia y factores de riesgo de la amputación de extremidades inferiores relacionada con la diabetes: estudio prospectivo de siete años en Costa Rica

Objective. To analyze the incidence and determinants of lower-extremity amputation(LEA) in people with diabetes in a low-income community in Costa Rica.Methods. Data on LEA incidence were collected during a seven-year follow-up (2001–2007) in a diabetes patient cohort (n = 572). Risk factors were analyzed using the Coxproportional hazards regression model and baseline variables from the year 2000 (sociodemographiccharacteristics, comorbidity, metabolic control, treatment, and chronic microvascularcomplications).Results. LEA incidence was 6.02 per 1 000 person-years (8.65 in men and 4.50 in women).Known risk factors (sex, years of diabetes, elevated glycated hemoglobin [HbA1c], retinopathy,insulin therapy, and prior amputation) were highly significant.Conclusions. Those most likely to undergo LEA among Costa Rican diabetic patients weremen with 10 or more years of diabetes and average HbA1c ≥ 8% who used insulin and haddiabetic retinopathy. Patients on insulin therapy were at greatest risk, especially those with aprevious amputation. Diabetic patients with the above-mentioned profile should be consideredto be at very high risk of LEA and followed closely by the health care system.

Objetivo. Analizar la incidencia y los determinantes de la amputación deextremidades inferiores (AEI) en personas diabéticas de una comunidad con bajosingresos de Costa Rica.Métodos. Se recopilaron datos sobre la incidencia de la AEI durante un período deseguimiento de siete años (del 2001 al 2007) en una cohorte de pacientes diabéticos(n = 572). Se analizaron los factores de riesgo usando el modelo de regresión de Coxde riesgos proporcionales y los valores de referencia del año 2000 de las variables(características sociodemográficas, comorbilidad, control metabólico, tratamiento ycomplicaciones microvasculares crónicas).Resultados. La incidencia de la AEI fue de 6,02 por 1 000 personas-año (8,65 envarones y 4,50 en mujeres). Los factores de riesgo conocidos (sexo, años de evoluciónde la diabetes, glucohemoglobina [HbA1c] elevada, retinopatía, tratamiento coninsulina y amputación previa) fueron muy significativos.Conclusiones. Los pacientes diabéticos costarricenses con mayor probabilidad desufrir una AEI fueron los varones con 10 o más años de evolución de la diabetesy un promedio de HbA1c ≥ 8% que eran tratados con insulina y padecían unaretinopatía diabética. Los pacientes en tratamiento con insulina presentaban el mayorriesgo, especialmente los que habían sufrido una amputación anterior. Los pacientesdiabéticos con el perfil descrito anteriormente deben considerarse como de riesgomuy elevado de AEI y deben ser seguidos de cerca por el sistema de atención desalud.

Resultados del tratamiento con revascularización distal y ligadura intermedia, de la isquemia de mano después de acceso vascular para hemodiálisis / Distal revascularization-interval ligation for ischemic steal syndrome after hemodialysis access: experience in 23 patients

Background: The creation of vascular accesses for hemodialysis can cause distal ischemia and steal syndromes. Aim: To assess the effectiveness of the technique of distal revascularization-interval ligation to alleviate distal ischemia and preserve vascular access. Material and Methods: Retrospective review of medical records, identifying 23 patients (13 women, aged between 24 and 79 years), with distal ischemia secondary to a vascular access for hemodialysis, that were treated with distal revascularization-interval liga-tion. Patient characteristics and outcome of the surgical procedure were recorded. Results: Fourteen patients were diabetic and 15 had high blood pressure. All had the vascular access in the elbow, 20 were done with vein and three were prosthetic. Steal appeared in a lapse ranging from hours to six years after performing the procedure. In 14 patients it appeared before 12 months. Revascularization was performed between 1 day and three months after the appearance of the steal syndrome. Seventeen patients (74 percent) had a substantial relief of ischemic symptoms, with healing of ulcers and digital amputations. Three patients died soon after the procedure (13 percent). In two the pain persisted, requiring a banding of the access, that finally became thrombosed. One patient required a distal forearm amputation. Thirteen patients (56 percent) had a late death after the procedure. After revascularization, the vascular accesses were used for a mean of two years. Conclusions: Revascularization-interval ligation relieves distal ischemia and maintains the patency of the vascular access for hemodialysis. Patients with steal syndrome secondary to vascular access are of high risk.

Objetivo: Investigar la efectividad de la técnica de revascularización distal y ligadura intermedia (RDLI) en aliviar la isquemia y preservar el acceso arteriovenoso. Material y Métodos: Una revisión retrospectiva de fichas clínicas (1990-2010), identificó 26 pacientes con robo. Se excluyen 3, que se sometieron a ligadura del acceso; 23 fueron tratados con RDLI. Se obtuvo información demográfica, comorbilidades, antecedentes del acceso, morbimortalidad y respuesta al tratamiento. Resultados: De los 23 pacientes, 13 eran mujeres y 10 hombres, con edad promedio de 59 años (24-79 años). Catorce (61 por ciento) eran diabéticos y quince (65 por ciento) hipertensos. Todos con acceso en pliegue del codo, 20 con vena y 3 protésicos. La latencia en aparición del robo ocurrió antes de 12 meses, en 14 pacientes (78 por ciento); con rango desde horas a 6,5 años. La revascularización se realizó en tiempo variable entre 1 día y 13 meses; sólo 8 pacientes antes de los 30 días. El 74 por ciento de los pacientes (17), tuvo mejoría sustancial o completa de manifestaciones isquémicas, cicatrizando úlceras y amputaciones digitales. Tres fallecieron precozmente; en 2 pacientes, persistió el dolor, requiriendo banding del acceso, que finalmente se trombosó; un paciente debió ser amputado del antebrazo distal, pese a revascularización, al no ceder cuadro infeccioso. La mortalidad operatoria fue de 13 por ciento, correspondiendo a 3 pacientes muy deteriorados con isquemia severa. La mortalidad tardía fue de 56,5 por ciento (13 pacientes). El tiempo promedio de uso del acceso fue de 2 años, post revascularización. Conclusión: La RDLI es el procedimiento de elección en el tratamiento del robo, ya que elimina efectivamente la isquemia y mantiene en uso el acceso. Los pacientes con robo, especialmente diabéticos, representan un grupo de alto riesgo y mortalidad.

Midgut volvulus after laparoscopic appendectomy / Volvo de intestino delgado após apendicectomia laparoscópica

The authors report a case of a 13-year old child who was submitted to a laparoscopic appendectomy and developed, during the postoperative period, an intestinal obstruction caused by small bowel volvulus in the absence of a congenital malrotation.

Relato do caso de uma criança de 13 anos de idade submetida à apendicectomia laparoscópica e que, no pós-operatório, desenvolveu quadro de obstrução intestinal, decorrente de um volvo de intestino delgado, na ausência de má rotação intestinal.

Emergency autologous vein graft reconstruction after using a vascular closure device / Reconstrução de emergência de enxerto autólogo de veia após uso de dispositivo de fechamento vascular

An emergency operation for access related acute critical limb ischemia with signs of infection is described. Inguinal femoral reconstruction was performed with a bifurcated graft constructed from the ipsilateral saphenous vein.

Uma operação de emergência relacionada à isquemia aguda com sinais de infecção é descrita. Reconstrução femoral inguinal foi realizada com um enxerto bifurcado feito a partir da veia safena ipsilateral.

Tratamento de angina mesentérica em pacientes com arterite de Takayasu / Treatment of mesenteric angina in patients with Takayasu's arteritis

Aarterite de Takayasu (AT) é uma doença inflamatória crônica do tecido conectivo, idiopática, que acomete preferencialmente a aorta e seus ramos. A terapêutica utilizada baseia-se sobretudo no uso de corticosteroides e imunossupressores. É relatado o caso de uma paciente, 33 anos, com mal-estar, febre, mialgia, cefaleia intensa, pulsátil, holocraniana, resistente a analgésicos, hipertensão arterial sistêmica de difícil controle, claudicação no membro inferior direito e dor abdominal de forte intensidade, a qual piorava após a alimentação. A angiotomografia revelou aneurisma da aorta ascendente, estenose da artéria ilíaca comum direita, estenose das artérias renais e estenose da artéria mesentérica superior, fato que embasou o diagnóstico de angina mesentérica e a conduta intervencionista através da angioplastia transluminal percutânea múltipla com a colocação de stents.

Takayasu's arteritis (TA) is an idiopathic chronic inflammatory disease of the connective tissue that affects mainly the aorta and its branches. Treatment is mainly based on corticosteroids and immunosuppressants. We report the case of a 33-year-old female complaining of malaise, fever, myalgia, severe pulsing holocranial headache resistant to analgesics, systemic arterial hypertension hard to control, right lower limb claudication, and severe abdominal pain that worsened after the meals. Angiotomography revealed aneurysm of the ascending aorta, and stenosis of the following vessels: right common iliac artery, renal arteries, and superior mesenteric artery. Those findings supported the diagnosis of mesenteric angina and the interventional approach by use of percutaneous transluminal angioplasty with stent placement.

Isquemia mesentérica crónica, tratamiento quirúrgico: reporte de dos casos / Chronic mesenteric ischemia: report of two cases

Chronic mesenteric ischemia is uncommon and often not recognized by clinicians. We report two patients with the disease. A 61 years old female with a two years history of abdominal pain, diarrhea, anorexia and weight loss. A mesenteric arteriography showed a critical stenosis of the celiac artery. The patient was operated and a retrograde bypass from the iliac to the mesenteric artery was placed. Digestive symptoms ceased and the patient gained weight. A 49 years old smoker female, with a two years history of abdominal pain and weight loss, without diarrhea. A doppler ultrasonography of abdominal arteries showed a critical stenosis of the celiac artery. The angiography confirmed the stenosis and disclosed also a complete occlusion of the common hepatic artery. The patient was operated placing anterograde aortic-mesenteric and aortic- hepatic bypasses. During the follow up, the patient is in good conditions.

La isquemia mesentérica crónica es una enfermedad que pone en riesgo la vida, que puede provocar la muerte por inanición o infarto mesentérico. El diagnóstico se realiza tardíamente debido a la inespecificidad de sus síntomas. El método diagnóstico no invasivo de elección es la ecografía doppler, por el cual se determina la presencia de estenosis u oclusión de las arterias viscerales comprometidas. La arteriografía se utiliza para definir la anatomía de las lesiones y planificar la cirugía. El tratamiento de elección sigue siendo la revascularización. Presentamos dos pacientes tratadas en nuestro servicio con buenos resultados, las que presentaban historia de síntomas abdominales inespecíficos y baja de peso. En la primera paciente, con antecedentes de hipercolesterolemia, su estudio demostró ateromatosis calcica difusa de aorta abdominal, ilíacas comunes, tronco celíaco, renales y mesentérica superior; se le realizó bypass ilíaco-mesentérico superior. En la segunda paciente, con antecedentes de tabaquismo crónico, su estudio demostró lesiones críticas de tronco celíaco y arteria mesentérica superior e inferior, se le realizó bypass aorto-mesentérico superior y aorto-hepático común. En los controles, ambas pacientes presentan alza de peso sostenida y se mantienen asintomáticas.

Clinical Effectiveness of Percutaneous Angioplasty for Acute and Chronic Mesenteric Ischemia: A Six Case Series / 대한소화기학회지

Intestinal ischemia is divided into three categories, namely, acute mesenteric ischemia (AMI), chronic mesenteric ischemia (CMI), and colonic ischemia. AMI can result from arterial or venous thrombi, emboli, and vasoconstriction secondary to low-flow states. It is an urgent condition which can result in high mortality rate. The predominant causative factor of CMI is stenosis or occlusion of the mesenteric arterial circulation, and it is characterized by postprandial abdominal pain and weight loss. Surgery is the treatment of choice for intestinal ischemia. However, it has been recently reported that percutaneous transluminal angioplasty with stent placement and/or thrombolysis is an effective therapy in various types of mesenteric ischemia. We report six cases of mesenteric ischemia which were successfully treated by percutaneous angioplasty, and review the literature from South Korea.